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M9490305.TXT
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1994-09-19
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Document 0305
DOCN M9490305
TI Superior sagittal sinus thrombosis in a patient with acquired
immunodeficiency syndrome.
DT 9411
AU Doberson MJ; Kleinschmidt-DeMasters BK; Department of Pathology,
University of Colorado Health Sciences; Center, Denver 80262.
SO Arch Pathol Lab Med. 1994 Aug;118(8):844-6. Unique Identifier : AIDSLINE
MED/94338265
AB A 41-year-old man with acquired immunodeficiency syndrome was admitted
to the hospital because of a recent onset of disorientation and memory
loss. He developed focal neurologic signs on hospital day 4, and a
computed tomographic scan of his head showed a right medial temporal
lobe hyperdensity. Before diagnosis could be made or treatment started,
the patient was unexpectedly found dead on hospital day 14. At autopsy,
a primary central nervous system B-cell immunoblastic lymphoma was found
involving both hippocampi and other periventricular areas. Associated
angiodestruction and necrosis with local vascular thrombosis were seen.
In addition, there was extensive, partial thrombosis of the superior
sagittal sinus and distal superficial cortical veins unassociated with
cerebral hemorrhage or infarction, lymphoma, or involvement with
opportunistic organisms. Retrospective review of radiographic studies
demonstrated the classic empty delta sign. To our knowledge, cerebral
venous and dural sinus thrombosis has not been well documented in
patients with the acquired immunodeficiency syndrome. Because the dural
venous sinuses are not routinely examined at autopsy in many
institutions, cerebral venous/dural sinus thrombosis in patients with
the acquired immunodeficiency syndrome may be more frequent than is
presently recognized.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Case Report
Central Nervous System Neoplasms/COMPLICATIONS Human Lymphoma,
B-Cell/COMPLICATIONS Lymphoma, Lymphoblastic/COMPLICATIONS Magnetic
Resonance Imaging Male Sinus
Thrombosis/*COMPLICATIONS/DIAGNOSIS/PATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).